Enantioselective hydrogenation of -aminomethylacrylates containing a free NOH group for the synthesis of -amino acid derivatives
نویسندگان
چکیده
We describe highly enantioselective synthesis of -amino acid derivatives (1a-c) using asymmetric hydrogenation of -aminomethylacrylates (2a-c), which contain a free basic NOH group, as the key step. The -aminomethylacrylates (2a-c) were prepared using the Baylis– Hillman reaction of an appropriate aldehyde with methyl acrylate followed by acetylation of the resulting allylic alcohols (4a-b) and SN2 -type amination of the allylic acetates (3a-b).
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